Psoriasis is an autoimmune disease with a repetitive course, different phenotypes, clinical assortments and a negative combination of genesis factors with possible detection of chronic diseases.According to literature, the spread of the psoriasis of the world is 4-7%.
According to Reyix, the light forms of the disease that affects 3-5% of the body area and the patient's immune status requires only local treatment.The psoriasis of the average and fierce course is a systematic, inflammatory process, causes the development or deterioration of the opposite pathology, and their themselves have a great impact on the patient's health and quality.
Psoriasis's treatment does not lose relevance, and despite the emergence of new modern treatment methods, it remains a difficult business that requires an ID card.
For the treatment of psoriasis, there is a wide selection of local and systematic drugs that model the immune system.When choosing an identity therapy, the spread of psoriasis and violence, process, its clinical form, as well as attitude towards the patient's disease.Thus, with rash localization in the skin of the skin - the hairy part of the face, head and brush, the disease has a significant impact on the quality of life and leads to heavy psycho -emo -ological practices.According to G. Krueger et al education.(2001) 40% of patients with psoriasis were disappointed in the neutralism of treatment, and 32% of treatment was considered insufficient.
System therapy of psoriasis
In the form of a tablet, systemic glucocorticoids are quite rare related to numerous side effects.However, the "ambulance" medication is advised to use long-term glucolomes for the intramuscular control to stabilize the psorial process with a progressive stage.A similar approach to the therapy avoids negative side effects.
In the treatment of Psoriasis, methotrexate is used for more than 40 years.Its movement mechanism is connected to the donor of simple carbon groups with simple carbon groups in synthesis, which turns acid into DNA Dihydrophology to Tetrahydrofolik and DNA synthesis.In this regard, the purpose of the form of folic acid helps prevent metabolic anemia.
Cyclosporin, which is a cyclosporin, which is a cyclosporin, which is a cyclosporin, which is a cyclosporin, which is the immune system, which has a cyclosporine, which is the immune system, which is a cyclosporin, which has a cyclosporin.The drug has high efficiency in the treatment of psoriasis, psorized eritorrhery.
Since 1997, the second generation's aromatic retinoids were used to treat psoriasis refractory forms, and this is the basis of this chemical formula.The drug has an immunomodulating effect, which prevents the spread of epidermis cells.The effectiveness of the product depends on the dose: higher doses cause psorial rash to a faster solution.
Relatively, a new group of new drugs appeared - biological medications containing biotechnological substances, which are synthesized by biotechnology by live cells of animals, plants and microorganisms.Tips for the recipe of biological drugs are severe forms of continuous psoriasis for other system medicines.
The treatment of psoriasis is treated with several chronic diseases, such as patient's metabolic syndrome, cardiovascular syndrome, cardiovascular syndrome, cardiovascular diseases, diabetes, diabetes, diabetes and lipid metabolic diseases.According to statistical research, such conditions for psoriasis are more observed than a general population.Thus, the side effects of the continued system of systematic therapy, the conditions of a few chronic diseases found individually in each patient in each patient.Indeed, some pharmacological drugs may have a negative impact on cardiovascular and metabolic positive diseases.The connection between psoriasis and heart-metabolic disorders has important clinical results.First, the systemic therapy of psoriasis can have a negative impact on metabolic positive diseases, especially in a sustainable and long period of treatment.In particular, methotrexate should be assigned carefully in obesity, diabetes, disease, free oil disease due to the increase in the risk of liver fibrosis.Cyclosporine or arterial hypertension can increase the appearance or voltage, increase insulin resistance and affect the metabolism of fatty acids, have a poisonous effect.
Acitrotin also helps hypertricureseridemia and / or hypercolesterolemia.Thus, while taking patients with Psoriasis, all the information should be taken into account.
A special place in the treatment of psoriasis is given photocopy.The positive impact of the ultraviolet radiation in the skin is associated with the selection inhibition of intimacy.According to literature, the movement of phototherapy differs: the following areas: artificial inhibition of artificial inhibition of inviolability and antiuliah.The impact of ultraviolet rays is associated with the depth of influence.UFB rays affect epidermal keratinocytes and Langergan cells, the Ufa rays penetrate deeper layers of the skin and affect the dermal fibroblasts, cells and cells of the immune system.The positive effect of the ultraviolet radiation, the decrease in cell apoptosis, langerganes cells, cytokines, growth factors (EGF, VEGF), adhesion and neuropeptides are related to the change of molecules.The purpose of phototherapy is recommended for a general skin process.
In the treatment of psoriasis, photocopootherapy (bullet-therapy) are used - long wave is used in the ultraviolet rays (Ufa) (320-400 Nm) and photosensitizing (8 metrops).PUVA-therapy is one of the most effective methods for psoriasis, is recommended by the general vulgar and exuding psoriasis, the stubborn path of the disease, severe infiltration.The treatment is 20-30 in the course, according to 3 or 4-RAF radiation methodology per week.
Currently, selective photocipary, wave radiation combination (280-320 Nm) has lost its position and has been less and less for the treatment of psoriasis.The purpose of the goal is to characterize the compounds, which are the lower composition of inflammatory cells.
A narrow striped UFB therapy, which is a peak of wave length emissions with high therapeutic efficiency, can be compared with a bullet-therapy, but unlike it does not require a photosensitizer.3-5 RAF per week is carried out by 20-30 procedures for the radiation methodology.
To treat a limited vulgar psoriasis, it is a negative laser that allows the monochromatic light of high-effective therapeutic techniques in a stationary phase, 308 Nm long intensity of 308 Nm long.
Local therapy
For the treatment of psoriasis, a fairly large selection of local products, especially in traditional ointments, especially tar, naphthalene, youthyol and salicylic acid.
When choosing topical therapy, the individual approach is as important as it depends on the patient's compatibility with the psoriasis.Thus, 40% of patients do not match the destination due to cosmetic potential of treatment.
The effectiveness of the topic corticosteroid drugs in the treatment of psoriasis is based on effects of effects on the reduction in inflammation of the inflammation.The action is associated with the mechanism of hormones and receptors complex, penetrates the core of the mobile cell and increases the expression of genes that encoded the synthesis of peptides that prevent the activities of Phospholipaz.This mechanism leads to a decrease in the formation of inflammatory mediators of phospholipids.Creams with integrated corticosteroid ointment and salicity acid are especially preferred.Preparations for local corticosteroids are not shown for long-term treatment and combinations and rotation schemes, skintrofiaosis, hypertrishosis, telangiectasia, steroids can cause side effects such as the oppression of steroids and adrenal function.
Vitamin D3 synthetic analogues have set themselves well by highly effective means of psoriasis.The most famous of this group is calcipotriol.The principle of the medication is based on the impact of the keratinized skin vitaminous part of the keratinized skin: the spread of skin differences in keratinocytes and models, especially reduces IL-2 and data expression.Calcipotriol has aggregate effects and therefore the therapeutic effect is observed 1-2 weeks later.From the beginning of treatment.
Unlike topical steroids, this group of this group is possible for a long time.To get a maximum therapeutic effect, the integrated goal of calcicotriol and topical steroids is possible.
The movement of local calcineurin inhibitors (Takrolimimus and Pimecrolimi) is associated with the signal transfer of T-lymphocytes by blocking Kalceurin's barrier.In case of localization of rashes, this group is the most expedient to determine the medicine, because they do not have such effects as a pressing steroid.
The cost of use of the mitigation substances in the treatment of sounds is doubt: soften the skin, reduces peeling and drying, especially after exposure to ultraviolet;to help reduce itching.After contact with water (bath, shower), the biggest impact is achieved when applying to the wet skin.The use of psoriasis in complex therapy is reduces the total value of treatment that helps patients stay in the hospital in the hospital as a result of the use of the disease and the start of remission.
Thus, according to the compliance of patients with patients and promising patients with psoriasis and promising patients primarily, according to patients with psoriasis and promising patients, it provides an effective approach to therapy.